Elastin-Based Rubber-Like Hydrogels

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• 作者：Malav S. Desai ; Eddie Wang ; Kyle Joyner ; Tae Won Chung ; Hyo-Eon Jin ; Seung-Wuk Lee
• 刊名：Biomacromolecules
• 出版年：2016
• 出版时间：July 11, 2016
• 年：2016
• 卷：17
• 期：7
• 页码：2409-2416
• 全文大小：525K
• 年卷期：0
• ISSN：1526-4602

文摘

We developed rubber-like elastomeric materials using a natural elastin derived sequence and genetic engineering to create precisely defined elastin-like polypeptides. The coiled elastin-like polypeptide chains, which behave like entropic springs, were cross-linked using an end-to-end tethering scheme to synthesize simple hydrogels with excellent extensibility and reversibility. Our hydrogels extend to strains as high as 1500% and remain highly resilient with elastic recovery as high as 94% even at 600% strain, significantly exceeding any other protein-based hydrogel. These materials are valuable as elastomeric hydrogels for designing extremely robust scaffolds useful for tissue engineering.