文摘
Four new polyketide synthase鈥搉onribosomal peptide synthetase (PKS鈥揘RPS) hybrid metabolites, pericoannosin A (1), with an unusual hexahydro-1H-isochromen-5-isobutylpyrrolidin-2-one skeleton, and three cytochalasans, periconiasins D鈥揊 (2鈥?b>4), were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were elucidated through extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu K伪). A possible biogenetic pathway is proposed. Compounds 1 and 4 showed anti-HIV activity with IC50s of 69.6 and 29.2 渭M, respectively.