Highly Regioselective 伪-Chlorination of the BODIPY Chromophore with Copper(II) Chloride

详细信息    查看全文

• 作者：Xin Zhou ; Changjiang Yu ; Zeya Feng ; Yang Yu ; Jun Wang ; Erhong Hao ; Yun Wei ; Xiaolong Mu ; Lijuan Jiao
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：17
• 期：18
• 页码：4632-4635
• 全文大小：373K
• ISSN：1523-7052

文摘

A general and efficient method for 伪-chlorination of 4,4鈥?difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPYs) has been developed using CuCl₂ as chlorination reagent. The reaction is characterized by complete 3/5-positions of BODIPY regioselectivity. This unusual highly regioselective 伪-halogenation of BODIPY is in sharp contrast to previously reported halogenation methods which preferred to occur first at the 2,6-positions of BODIPY. This approach provides a straightforward, facile, and economical route to 3- and/or 5-chloroBODIPYs with various meso-groups (H, alkyl, and aryl) and their derivatives.