Rhodium(II)-Catalyzed C–H Functionalization of Electron-Deficient Methyl Groups

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• 作者：Liangbing Fu ; David M. Guptill ; Huw M. L. Davies
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：May 11, 2016
• 年：2016
• 卷：138
• 期：18
• 页码：5761-5764
• 全文大小：409K
• 年卷期：0
• ISSN：1520-5126

文摘

Enantioselective C–H functionalization of relatively electron-deficient methyl sites was achieved with the combination of 2,2,2-trichloroethyl aryldiazoacetates and tetrakis(triarylcyclopropanecarboxylate) dirhodium catalysts. The substrate scope of the transformation was relatively broad, and C–H functionalization products were furnished with excellent levels of enantioselectivity. As a strategic reaction, crotonate derivatives give 1,6-dicarbonyl compounds, which are useful for further diversification.