Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C鈥揘 Coupling with Chiral Bisphosphine Mono-oxides
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- 作者：Hongming Li ; Kevin M. Belyk ; Jingjun Yin ; Qinghao Chen ; Alan Hyde ; Yining Ji ; Steven Oliver ; Matthew T. Tudge ; Louis-Charles Campeau ; Kevin R. Campos
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：November 4, 2015
- 年：2015
- 卷：137
- 期：43
- 页码：13728-13731
- 全文大小：373K
- ISSN：1520-5126
文摘
A novel approach to hemiaminal synthesis via palladium-catalyzed C鈥揘 coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N-acetals.