N-(2-Mercaptoethyl)picolylamine as a Diaminomonothiolate Ligand for the "fac-[Re(CO)3]+" Core

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• 作者：Daniel J. Kramer ; Alan Davison ; William M. Davis ; and Alun G. Jones
• 刊名：Inorganic Chemistry
• 出版年：2002
• 出版时间：December 2, 2002
• 年：2002
• 卷：41
• 期：24
• 页码：6181 - 6183
• 全文大小：66K
• 年卷期：v.41,no.24(December 2, 2002)
• ISSN：1520-510X

文摘

N-(2-Mercaptoethyl)picolylamine (MEPAH) was studied as apotentially biologically relevant ligand for the "fac-[M(CO)₃]⁺" core(M = Re, ⁹⁹Tc, ^99mTc). To this end, the complex Re(CO)₃(MEPA)was synthesized. The reaction of MEPAH with fac-[Re(CO)₃(MeCN)₃]⁺ took place over the course of seconds, showing thehigh affinity possessed by this ligand for the "fac-[Re(CO)₃]⁺" core.A single-crystal X-ray diffraction study was performed confirmingthe nature of Re(CO)₃(MEPA), a rare mononuclear rhenium(I)thiolate complex. Additional exploration into derivatization of theligand backbone has afforded the analogous N-ethyl complex, Re(CO)₃(MEPA-NEt). The high affinity of the ligand for the metalcoupled with the ease of its derivatization implies that utilizationof this ligand system for the purposes of ^99mTc-radiopharmaceuticaldevelopment is promising.