Synthesis of cis-[Cr(diimine)2(1-methylimidazole)2]3+ Complexes and an Investigation of Their Interaction with Mononucleotides and Polynucleotides
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- 作者：Sarah K. Goforth ; Thomas W. Gill ; April E. Weisbruch ; Kimberlee A. Kane-Maguire ; Marian E. Helsel ; Katherine W. Sun ; Hillary D. Rodgers ; Floyd E. Stanley ; Samuel R. Goudy ; Sandra K. Wheeler ; John F. Wheeler ; Noel A. P. Kane-Maguire
- 刊名：Inorganic Chemistry
- 出版年：2016
- 出版时间：February 15, 2016
- 年：2016
- 卷：55
- 期：4
- 页码：1516-1526
- 全文大小：490K
- ISSN：1520-510X
文摘
A protocol is presented for the synthesis of chromium(III) complexes of the type cis-[Cr(diimine)2(1-methylimidazole)2]3+. These compounds exhibit large excited-state oxidizing powers and strong luminescence in solution. Emission is quenched by added guanine, yielding rate constants that track the driving force for guanine oxidation. The cis-[Cr(TMP)(DPPZ)(1-MeImid)2]3+ species binds strongly to duplex DNA with a preference for AT base sites in the minor groove and may serve as a precursor for photoactivated DNA covalent adduct formation.