Ultrasensitive Mercury Ion Detection Using DNA-Functionalized Molybdenum Disulfide Nanosheet/Gold Nanoparticle Hybrid Field-Effect Transistor Device

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• 作者：Guihua Zhou ; Jingbo Chang ; Haihui Pu ; Keying Shi ; Shun Mao ; Xiaoyu Sui ; Ren Ren ; Shumao Cui ; Junhong Chen
• 刊名：ACS Sensor
• 出版年：2016
• 出版时间：March 25, 2016
• 年：2016
• 卷：1
• 期：3
• 页码：295-302
• 全文大小：591K
• ISSN：2379-3694

文摘

Mercury, one of the most harmful pollutants in water, has a significant negative impact on human health. The molybdenum disulfide (MoS₂) nanosheet, due to its unique electronic properties, is a promising candidate for high-performance sensing materials. Here, we report a DNA-functionalized MoS₂ nanosheet/gold nanoparticle hybrid field-effect transistor (FET) sensor for the ultrasensitive detection of Hg²⁺ in an aqueous environment. Specific DNA was used in the hybrid structure as the capture probe for the label-free detection. By monitoring the electrical characteristics of the FET device, the performance of the sensor was investigated. Our sensor shows a rapid response (1–2 s) to Hg²⁺ and an ultralow detection limit of 0.1 nM, which is much lower than the maximum contaminant level (MCL) for Hg²⁺ in drinking water (9.9 nM) recommended by the U.S. Environmental Protection Agency (EPA). In addition, the sensor shows a high selectivity to Hg²⁺ compared with other interfering metal ions, e.g., As⁵⁺, Cd²⁺, Pb²⁺, and so forth. This rapid and ultrasensitive method for Hg²⁺ detection can either be potentially developed into stand-alone hand-held sensors or be integrated into existing water equipment for continuously monitoring the water quality.