Total Synthesis of (+)-Hygrine via Asymmetric Phase-Transfer Catalytic Alkylation

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• 作者：Jeong-Hee Lee ; Byeong-Seon Jeong ; Jin-Mo Ku ; Sang-sup Jew ; Hyeung-geun Park
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：August 18, 2006
• 年：2006
• 卷：71
• 期：17
• 页码：6690 - 6692
• 全文大小：58K
• 年卷期：v.71,no.17(August 18, 2006)
• ISSN：1520-6904

文摘

The first enantioselective synthesis of (+)-hygrine (1) isreported. 1 was obtained in 12 steps with 29% overall yieldand 97% ee via asymmetric phase-transfer catalytic alkylationand ring-closing metathesis as key steps. The absolute configuration of (+)-hygrine could be directly confirmed as R.