Highly Enantioselective Hydrogenation of Steric Hindrance Enones Catalyzed by Ru Complexes with Chiral Diamine and Achiral Phosphane

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• 作者：Xiangning Chen ; Han Zhou ; Kunyu Zhang ; Jiawen Li ; Hanmin Huang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 1, 2014
• 年：2014
• 卷：16
• 期：15
• 页码：3912-3915
• 全文大小：310K
• ISSN：1523-7052

文摘

An asymmetric hydrogenation of sterically hindered 尾,尾-disubstituted enones has been well-established by using a ruthenium complex composed of an achiral diphosphane and a chiral diamine as catalyst, wherein the carbonyl group was selectively hydrogenated to give a wide range of chiral allylic alcohols with high levels of enantioselectivity and complete chemoselectivity.