New Class of Heterogeneous Helical Peptidomimetics

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• 作者：Haifan Wu ; Qiao Qiao ; Peng Teng ; Yaogang Hu ; Dimitrios Antoniadis ; Xiaobing Zuo ; Jianfeng Cai
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：17
• 期：14
• 页码：3524-3527
• 全文大小：289K
• ISSN：1523-7052

文摘

A new class of unnatural heterogeneous foldamers is reported to contain alternative 伪-amino acid and sulfono-纬-AA amino acid residues in a 1:1 repeat pattern. Two-dimensional NMR data show that two 1:1 伪/sulfono-纬-AA peptides with diverse side chains form analogous right-handed helical structures in solution. The effects of sequence length, side chain, N-capping, and temperature on folding propensity were further investigated using circular dichroism and small-angle X-ray scattering.