New Sweet-Tasting C21-Pregnane Glycosides from Pericarps of Myriopteron extensum
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- 作者：Guo Sun ; Qin Dai ; Hong-Xia Zhang ; Zhi-Jian Li ; Zhi-Zhi Du
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2016
- 出版时间：December 14, 2016
- 年：2016
- 卷：64
- 期：49
- 页码：9381-9389
- 全文大小：420K
- ISSN：1520-5118
文摘
Ten novel C21 pregnane glycosides, extensumside C–L (1–10), were isolated as highly sweet-tasting substances from the edible pericarps of Myriopteron extensum (Wight) K. Schum by sensory-guided fractionation and purification. Their structures were determined through 1D and 2D NMR, such as HSQC, HMBC, 1H–1H COSY, HSQC-TOCSY, and ROESY, as well as other spectroscopic analysis combined with chemical evidence. These compounds shared the same aglycone, 3β,16α-dihydroxy-pregn-5-en-20-one, and contained the deoxysugar chain and the glucose chain which were linked to C-3 and C-16 of the aglycone, respectively. The sweetness potency was evaluated by a human sensory panel test and preliminary structure–taste relationship was discussed. The sweetness intensities of these compounds are between 50 and 400 times greater than that of sucrose. Furthermore, quantitation analyses of compounds 1, 3, 4, and 6 in different parts of M. extensum indicated that the concentrations of these sweet components in the pericarps are obviously higher than those in stems and roots.