Development of a Palladium-Catalyzed 伪-Arylation of Cyclopropyl Nitriles

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• 作者：Jamie M. McCabe Dunn ; Jeffrey T. Kuethe ; Robert K. Orr ; Matthew Tudge ; Louis-Charles Campeau
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：December 19, 2014
• 年：2014
• 卷：16
• 期：24
• 页码：6314-6317
• 全文大小：349K
• ISSN：1523-7052

文摘

1,1-Disubstituted aryl cyclopropyl nitriles are useful moieties in biologically active compounds and provide access to a range of cyclopropyl derivatives. Herein, we describe the development of a palladium-catalyzed 伪-arylation of cyclopropyl, cyclobutyl, and cyclopentyl nitriles that affords these functional groups in one step from a variety of aryl bromides in good to excellent yields. Furthermore, we demonstrate the transformation of aryl cyclopropyl nitriles into aryl trifluoromethyl cyclopropanes.