Metal-Free Access to Fully Substituted Skipped Diynes. An Efficient Chemodifferentiating A2BB' 4CR Manifold

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• 作者：David Tejedor ; Sara Ló ; pez-Tosco ; Javier Gonzá ; lez-Platas ; Fernando Garc&iacute ; a-Tellado
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：July 6, 2007
• 年：2007
• 卷：72
• 期：14
• 页码：5454 - 5456
• 全文大小：87K
• 年卷期：v.72,no.14(July 6, 2007)
• ISSN：1520-6904

文摘

BLE>bscribe/journals/joceah/72/i14/figures/jo070764yn00002.gif" ALIGN="left" HSPACE=5>A metal-free chemodifferentiating A₂BB' 4CR manifold forthe modular synthesis of tertiary skipped diynes is described.The manifold performs a triethylamine triggered reaction ofalkyl propiolates and acid chlorides to assemble two unitsof each component in the form of two propargylic alkynoates,a tertiary alcohol, and an ester. A differentiated incorporationof the two acid chloride components ensures functionaldiversity in the final structure. In addition, the presence oftwo connected propargylic alkynoates provides a reactiveplatform for complexity generation.