A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis

详细信息    查看全文

• 作者：Tri H. V. Huynh ; Mette Louise H. Mantel ; Katrine Mikkelsen ; Anders T. Lindhardt ; Niels Chr. Nielsen ; Daniel Otzen ; Troels Skrydstrup*
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：February 19, 2009
• 年：2009
• 卷：11
• 期：4
• 页码：999-1002
• 全文大小：169K
• 年卷期：v.11,no.4(February 19, 2009)
• ISSN：1523-7052

文摘

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of β-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and ¹⁹F-BAY94-9172.