Polyketides from the Littoral Plant Associated Fungus Pseudallescheria boydii

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• 作者：Ya-Chih Chang ; Tzu-Shing Deng ; Ka-Lai Pang ; Che-Jen Hsiao ; Yi-Ying Chen ; Shye-Jye Tang ; Tzong-Huei Lee
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1796-1800
• 全文大小：264K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

Four previously unreported chemical entities, boydone A (1), boydone B (2), botryorhodine F (3), and botryorhodine G (4), along with five known compounds, fusidilactone A (5), (R)-(鈭?-mevalonolactone (6), (R)-(鈭?-lactic acid (7), ovalicin (8), and botryorhodine C (9), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Pseudallescheria boydii NTOU2362. The structures of 1鈥?b>9 were characterized on the basis of their spectroscopic data analyses. The absolute configurations of 1 and 2 were established by comparison with the literature and the modified Mosher鈥檚 method. The growth inhibitory activities of 1鈥?b>9 against the A549 non-small-cell lung cancer cell line were evaluated, and 2 and 8 exhibited moderate to potent bioactivities with GI₅₀ values of 41.3 and 4.1 渭M, respectively, in comparison with fluorouracil (GI₅₀ = 3.6 渭M).