TiO2 Printed Aluminum Foil: Single-Use Film for a Laser Desorption/Ionization Target Plate

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• 作者：Hongyan Bi ; Liang Qiao ; Jean-Marc Busnel ; Valerie Devaud ; Baohong Liu ; Hubert H. Girault
• 刊名：Analytical Chemistry
• 出版年：2009
• 出版时间：February 1, 2009
• 年：2009
• 卷：81
• 期：3
• 页码：1177-1183
• 全文大小：253K
• 年卷期：v.81,no.3(February 1, 2009)
• ISSN：1520-6882

文摘

Single-use aluminum foil-based laser desorption/ionization (LDI) target plates have been developed for mass spectrometry (MS) analysis and provide detection results comparable to those of commercial stainless steel plates while offering a convenient way to avoid the time-consuming surface cleaning process. Additionally, arrays of TiO₂ nanoparticle spots are coated on the foil either by screen-printing or rotogravure-printing followed by sintering to form a mesoporous layer spot to act as an anchor for sample deposition. These TiO₂ spots offer further functions to the Al foil, such as matrix-free laser desorption/ionization or specific affinity for in situ enrichment of phosphopeptides. The single-use TiO₂−Al foils are cheap to produce, easy to use, and well suited for high-throughput proteomics research. They can also be of interest for protein post-translational modifications study.