Formation Mechanism and Phase Transformation Behaviors of Pantoprazole Sodium Heterosolvate

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• 作者：Chen Jiang ; Yongli Wang ; Jiaqi Yan ; Jingxiang Yang ; Liping Xiao ; Hongxun Hao
• 刊名：Organic Process Research & Development
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：19
• 期：11
• 页码：1752-1759
• 全文大小：469K
• ISSN：1520-586X

文摘

In this paper, one new heterosolvate of pantoprazole sodium (PPS) was found, and its crystal structure was determined for the first time. It was found that both water molecules and acetone molecules get involved in the formation of crystal lattice of pantoprazole sodium heterosolvate. Powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), Raman spectroscopy, and infrared spectroscopy (IR) were used to identify and characterize PPS heterosolvate. The phase transformation behaviors between PPS monohydrate and PPS heterosolvate were also investigated. It was found that PPS monohydrate can transform into PPS heterosolvate through either vapor sorption or solvent-mediated transformation. PPS heterosolvate can also transform into PPS monohydrate in the presence of hexane vapor or upon heating. Furthermore, the kinetics and mechanisms of desolvation of PPS heterosolvate were systematically investigated.