Chemical Constituents of Propolis from Myanmar and Their Preferential Cytotoxicity against a Human Pancreatic Cancer Cell Line

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• 作者：Feng Li ; Suresh Awale ; Hongyan Zhang ; Yasuhiro Tezuka ; Hiroyasu Esumi ; Shigetoshi Kadota
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：July 24, 2009
• 年：2009
• 卷：72
• 期：7
• 页码：1283-1287
• 全文大小：156K
• 年卷期：v.72,no.7(July 24, 2009)
• ISSN：1520-6025

文摘

A methanolic extract of propolis obtained in Myanmar was found to inhibit PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions (NDM), with a PC₅₀ value of 9.3 μg/mL. Bioactivity-guided fractionation of the extract led to the isolation of two new cycloartane-type triterpenes, (22Z,24E)-3-oxocycloart-22,24-dien-26-oic acid (1) and (24E)-3-oxo-27,28-dihydroxycycloart-24-en-26-oic acid (2), together with 13 cycloartanes (3−13) and four known prenylated flavanones (14−17). Among these, compound 1 exhibited the most potent preferential cytotoxicity (PC₅₀ 4.3 μM) in a concentration- and time-dependent manner. Furthermore, 1 induced apoptosis-like morphological changes of PANC-1 cells within 24 h of treatment.