Palladium-Catalyzed C-2 Selective Arylation of Quinolines
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- 作者：Xiaoyu Ren ; Ping Wen ; Xiaokang Shi ; Yuling Wang ; Jian Li ; Sizhuo Yang ; Hao Yan ; Guosheng Huang
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：October 18, 2013
- 年：2013
- 卷：15
- 期：20
- 页码：5194-5197
- 全文大小：265K
- 年卷期：v.15,no.20(October 18, 2013)
- ISSN：1523-7052
文摘
An efficient method for the Pd-catalyzed regioselective C-2 arylation of quinolines is presented. Reactions of various substituted quinolines and unactivated arenes have been conducted under mild conditions. The result shows good product yields of 2-arylquinolines, which are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.