Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence

详细信息    查看全文

• 作者：Haoyuan Huang ; Saurabh Chauhan ; Jumin Geng ; Yiru Qin ; David F. WatsonJonathan F. Lovell
• 刊名：Biomacromolecules
• 出版年：2017
• 出版时间：February 13, 2017
• 年：2017
• 卷：18
• 期：2
• 页码：562-567
• 全文大小：474K
• ISSN：1526-4602

文摘

Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.