Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists
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- 作者：Takayoshi Suzuki ; Sou-ichi Igari ; Akira Hirasawa ; Mie Hata ; Masaji Ishiguro ; Hiroki Fujieda ; Yukihiro Itoh ; Tatsuya Hirano ; Hidehiko Nakagawa ; Michitaka Ogura ; Makoto Makishima ; Gozoh Tsujimoto ; Naoki
- 刊名：Journal of Medicinal Chemistry
- 出版年：2008
- 出版时间：December 11, 2008
- 年：2008
- 卷：51
- 期：23
- 页码：7640-7644
- 全文大小：194K
- 年卷期：v.51,no.23(December 11, 2008)
- ISSN：1520-4804
文摘
A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor γ (PPARγ) agonist 3. Modification based on the homology model of GPR120 led to the first GPR120-selective agonist 12. These results provide a basis for constructing new tools for probing the biology of GPR120 and for developing new candidate therapeutic agents.