Using Model-Based Screening to Help Discover Unknown Environmental Contaminants

详细信息    查看全文

• 作者：Michael S. McLachlan ; Amelie Kierkegaard ; Michael Radke ; Anna Sobek ; Anna Malmv盲rn ; Tomas Alsberg ; Jon A. Arnot ; Trevor N. Brown ; Frank Wania ; Knut Breivik ; Shihe Xu
• 刊名：Environmental Science & Technology
• 出版年：2014
• 出版时间：July 1, 2014
• 年：2014
• 卷：48
• 期：13
• 页码：7264-7271
• 全文大小：262K
• ISSN：1520-5851

文摘

Of the tens of thousands of chemicals in use, only a small fraction have been analyzed in environmental samples. To effectively identify environmental contaminants, methods to prioritize chemicals for analytical method development are required. We used a high-throughput model of chemical emissions, fate, and bioaccumulation to identify chemicals likely to have high concentrations in specific environmental media, and we prioritized these for target analysis. This model-based screening was applied to 215 organosilicon chemicals culled from industrial chemical production statistics. The model-based screening prioritized several recognized organosilicon contaminants and generated hypotheses leading to the selection of three chemicals that have not previously been identified as potential environmental contaminants for target analysis. Trace analytical methods were developed, and the chemicals were analyzed in air, sewage sludge, and sediment. All three substances were found to be environmental contaminants. Phenyl-tris(trimethylsiloxy)silane was present in all samples analyzed, with concentrations of 50 pg m^鈥? in Stockholm air and 0.5 ng g^鈥? dw in sediment from the Stockholm archipelago. Tris(trifluoropropyl)trimethyl-cyclotrisiloxane and tetrakis(trifluoropropyl)tetramethyl-cyclotetrasiloxane were found in sediments from Lake Mj酶sa at 1 ng g^鈥? dw. The discovery of three novel environmental contaminants shows that models can be useful for prioritizing chemicals for exploratory assessment.