Using Factorial Experimental Design To Prepare Size-Tuned Nanovesicles

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• 作者：Pablo García-Manrique ; María Matos ; Gemma Gutiérrez ; Oscar R. Estupiñán ; María Carmen Blanco-López ; Carmen Pazos
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2016
• 出版时间：August 31, 2016
• 年：2016
• 卷：55
• 期：34
• 页码：9164-9175
• 全文大小：599K
• 年卷期：0
• ISSN：1520-5045

文摘

The aim of this work was to prepare size-tuned nanovesicles using a modified ethanol injection method (EIM) by applying factorial experimental design. Stable size-tuned nanovesicles (liposomes and niosomes) with controlled sizes and high EE values for hydrophobic compounds (Sudan Red 7B and vitamin D₃) were achieved. Equations that were able to predict the mean particle sizes, in the ranges of 55–156 nm for liposomes and 224–362 nm for niosomes with PDI values between 0.032 and 0.378, were obtained. These customized soft nanoparticles could be suitable in food, cosmetic, pharmaceutical, or medical applications, such as diagnosis or therapy.