Design of an Integrated Process of Chromatography, Crystallization and Racemization for the Resolution of 2鈥?6鈥?Pipecoloxylidide (PPX)
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- 作者：Jan von Langermann ; Malte Kaspereit ; Mozaffar Shakeri ; Heike Lorenz ; Martin Hedberg ; Matthew J. Jones ; Kerstin Larson ; Bj枚rn Herschend ; Robert Arnell ; Erik Temmel ; Jan-Erling B盲ckvall ; Achim Kienle ; Andreas Seidel-Morgenstern
- 刊名：Organic Process Research & Development
- 出版年：2012
- 出版时间：February 17, 2012
- 年：2012
- 卷：16
- 期：2
- 页码：343-352
- 全文大小：440K
- 年卷期：v.16,no.2(February 17, 2012)
- ISSN：1520-586X
文摘
An integrated process for the chiral separation of the industrially relevant substance 2鈥?6鈥?pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %.