Tris(1,2-diphenylethylenediamine)cobalt(III) Complexes: Chiral Hydrogen Bond Donor Catalysts for Enantioselective α-Aminations of 1,3-Dicarbonyl Compounds

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• 作者：Anil Kumar ; Subrata K. Ghosh ; John A. Gladysz
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：18
• 期：4
• 页码：760-763
• 全文大小：448K
• ISSN：1523-7052

文摘

The enantiopure salt Δ-[Co((S,S)-dpen)₃]³⁺2Cl^–B(C₆F₅)₄^– is an effective hydrogen bond donor catalyst for additions of 1,3-dicarbonyl compounds to di-tert-butyl azodicarboxylate in the presence of N-methylmorpholine (1.0:1.0:0.10) in CH₃CN at 0 °C, as illustrated with educts derived from five- or six-membered ring ketones (99–88% yields, >99–91% ee) and cycloheptanone (94%, 72% ee) as well as 2-cyanocyclopentanone (92%, 45% ee) and an acyclic system (98%, >99% ee).