High-Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor

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• 作者：Csaba Csajá ; gi ; Bernadett Borcsek ; Krisztiá ; n Niesz ; Ildikó ; Ková ; cs ; Zsolt Sz&eacute ; kelyhidi ; Zoltá ; n Bajkó ; Lá ; szló ; Ü ; rge ; Ferenc Darvas
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：April 17, 2008
• 年：2008
• 卷：10
• 期：8
• 页码：1589 - 1592
• 全文大小：78K
• 年卷期：v.10,no.8(April 17, 2008)
• ISSN：1523-7052

文摘

Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzedaminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gasintroduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required lessthan 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses ofcompound libraries.