Synthesis of Aza-Fused Polycyclic Quinolines through Copper-Catalyzed Cascade Reactions

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• 作者：Qian Cai ; Zhengqiu Li ; Jiajia Wei ; Liangbin Fu ; Chengyong Ha ; Duanqing Pei ; Ke Ding
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：April 2, 2010
• 年：2010
• 卷：12
• 期：7
• 页码：1500-1503
• 全文大小：216K
• 年卷期：v.12,no.7(April 2, 2010)
• ISSN：1523-7052

文摘

A new and efficient method for the synthesis of aza-fused polycyclic quinolines (e.g., benzimidazo[1,2-a]quinolines) is described. This protocol includes an intermolecular condensation followed by a copper-catalyzed intramolecular C−N coupling reaction. The method is applied to a wide range of 2-iodo, 2-bromo, and 2-chloro aryl aldehyde substrates to yield the aza-fused polycyclic quinolines in good yields.