Chemosynthesis of Poly(蔚-lysine)-Analogous Polymers by Microwave-Assisted Click Polymerization

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• 作者：Jinshan Guo ; Ying Wei ; Dongfang Zhou ; Pingqiang Cai ; Xiabin Jing ; Xue-Si Chen ; Yubin Huang
• 刊名：Biomacromolecules
• 出版年：2011
• 出版时间：March 14, 2011
• 年：2011
• 卷：12
• 期：3
• 页码：737-746
• 全文大小：1068K
• 年卷期：v.12,no.3(March 14, 2011)
• ISSN：1526-4602

文摘

Poly(蔚-lysine) (蔚-PL)-analogous click polypeptides with not only similar 伪-amino side groups but also similar main chain to 蔚-PL were chemically synthesized for the first time through click polymerization from aspartic (or glutamic)-acid-based dialkyne and diazide monomers. With microwave-assisting, the reaction time of click polymerization was compressed into 30 min. The polymers were fully characterized by NMR, ATR-FTIR, and SEC-MALLS analysis. The deprotected click polypeptides had similar pK_a value (7.5) and relatively low cytotoxicity as 蔚-PL and could be used as substitutes of 蔚-PL in biomedical applications, especially in endotoxin selective removal. Poly(ethylene glycol) (PEG)-containing alternating copolymers with 伪-amino groups were also synthesized and characterized. After deprotection, the polymers could be used as functional gene vector with PEG shadowing system and NCA initiator to get amphiphilic graft polymers.