Surface-Enhanced Raman Spectroscopy Biosensing: In Vivo Diagnostics and Multimodal Imaging

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• 作者：Anne-Isabelle Henry ; Bhavya Sharma ; M. Fernanda Cardinal ; Dmitry Kurouski ; Richard P. Van Duyne
• 刊名：Analytical Chemistry
• 出版年：2016
• 出版时间：July 5, 2016
• 年：2016
• 卷：88
• 期：13
• 页码：6638-6647
• 全文大小：549K
• 年卷期：0
• ISSN：1520-6882

文摘

This perspective presents recent developments in the application of surface-enhanced Raman spectroscopy (SERS) to biosensing, with a focus on in vivo diagnostics. We describe the concepts and methodologies developed to date and the target analytes that can be detected. We also discuss how SERS has evolved from a “point-and-shoot” stand-alone technique in an analytical chemistry laboratory to an integrated quantitative analytical tool for multimodal imaging diagnostics. Finally, we offer a guide to the future of SERS in the context of clinical diagnostics.