Visible-Light-Promoted Radical C鈥揌 Trifluoromethylation of Free Anilines

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• 作者：Jin Xie ; Xiangai Yuan ; Ablimit Abdukader ; Chengjian Zhu ; Jing Ma
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：16
• 期：6
• 页码：1768-1771
• 全文大小：347K
• 年卷期：v.16,no.6(March 21, 2014)
• ISSN：1523-7052

文摘

The trifluoromethyl-substituted anilines are biologically active compounds and useful building blocks. In this communication, we have developed the first visible-light-induced radical trifluoromethylation of free anilines with the commercially available and easily handled Togni reagent at room temperature. The resulting products were successfully transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds. This protocol provides an economical and powerful route to trifluoromethylated free anilines.