Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species
详细信息 查看全文
- 作者：Sianne SchwikkardAlaa Alqahtani ; Walter Knirsch ; Wolfgang Wetschnig ; Andrius Jaksevicius ; Elizabeth I. Opara ; Moses K. Langat ; Jackie L. Andriantiana ; Dulcie A. Mulholland
- 刊名：Journal of Natural Products
- 出版年：2017
- 出版时间：January 27, 2017
- 年：2017
- 卷：80
- 期：1
- 页码：30-37
- 全文大小：377K
- ISSN：1520-6025
文摘
The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6–8), have been isolated and identified. Compounds 1–3 and 6–8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 μM compared to 12% for 1 mM aspirin (the positive control).