Photoassisted One-Step Aerosol Fabrication of Zwitterionic Chitosan Nanoparticles

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• 作者：Jeong Hoon Byeon ; Aditya Kulkarni ; Hee-Kwon Kim ; David H. Thompson ; Jeffrey T. Roberts
• 刊名：Biomacromolecules
• 出版年：2014
• 出版时间：June 9, 2014
• 年：2014
• 卷：15
• 期：6
• 页码：2320-2325
• 全文大小：411K
• 年卷期：v.15,no.6(June 9, 2014)
• ISSN：1526-4602

文摘

Zwitterionic chitosan nanoparticles (ZCNPs) were conveniently obtained by a one-step aerosol method, and their potential for the production of biocompatible materials was investigated. A low-molecular-weight chitosan was conjugated with succinic anhydride to produce zwitterionic chitosan (ZC). Collison-atomized ZC droplets were simultaneously UV-irradiated and dried in a tube furnace in a one-step aerosol process to produce particles. The observed cytotoxicities of ZCNPs (85 卤 3.9% cell viability) were similar to unmodified chitosan nanoparticles (CNPs, 88 卤 6.6%) and UV-irradiated ZCNPs (83 卤 3.3%). The aerosol process described in this work allowed facile production and modification of CNPs, which could then be employed for biomedical purposes.