Fabrication and Characterization of Electrospun Chitosan Nanofibers Formed via Templating with Polyethylene Oxide

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• 作者：Satyajeet S. Ojha ; Derrick R. Stevens ; Torissa J. Hoffman ; Kelly Stano ; Rebecca Klossner ; Mary C. Scott ; Wendy Krause ; Laura I. Clarke ; Russell E. Gorga
• 刊名：Biomacromolecules
• 出版年：2008
• 出版时间：September 8, 2008
• 年：2008
• 卷：9
• 期：9
• 页码：2523-2529
• 全文大小：343K
• 年卷期：v.9,no.9(September 8, 2008)
• ISSN：1526-4602

文摘

Chitosan is an abundantly common, naturally occurring, polysaccharide biopolymer. Its biocompatible, biodegradable, and antimicrobial properties have led to significant research toward biological applications such as drug delivery, artificial tissue scaffolds for functional tissue engineering, and wound-healing dressings. For applications such as tissue scaffolding, formation of highly porous mats of nanometer-sized fibers, such as those fabricated via electrospinning, may be quite important. Previously, strong acidic solvents and blending with synthetic polymers have been used to achieve electrospun nanofibers containing chitosan. As an alternative approach, in this work, polyethylene oxide (PEO) has been used as a template to fabricate chitosan nanofibers by electrospinning in a core-sheath geometry, with the PEO sheath serving as a template for the chitosan core. Solutions of 3 wt % chitosan (in acetic acid) and 4 wt % PEO (in water) were found to have matching rheological properties that enabled efficient core-sheath fiber formation. After removing the PEO sheath by washing with deionized water, chitosan nanofibers were obtained. Electron microscopy confirmed nanofibers of ∼250 nm diameter with a clear core-sheath geometry before sheath removal, and chitosan nanofibers of ∼100 nm diameter after washing. The resultant fibers were characterized with IR spectroscopy and X-ray diffraction, and the mechanical and electrical properties were evaluated.