Speeding Up a Bidirectional DNA Walking Device

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• 作者：Chunyan Wang ; Yu Tao ; Guangtao Song ; Jinsong Ren ; Xiaogang Qu
• 刊名：Langmuir
• 出版年：2012
• 出版时间：October 16, 2012
• 年：2012
• 卷：28
• 期：41
• 页码：14829-14837
• 全文大小：407K
• 年卷期：v.28,no.41(October 16, 2012)
• ISSN：1520-5827

文摘

A strategy to speed up DNA walking devices through the use of DNA catalysts has been developed. The DNA walker is designed to move on a three-foothold molecular track with the assistance of fuel strands. The movement can be accelerated in the presence of catalysts. The motor could be halted at a desired location by a simple control, and the locomotion is about 1 order of magnitude faster than previous hybridization-based walker. Additionally, one branch of the walker can be designed to capture and transfer protein or some other inorganic molecules along the designed track with easy control, which makes our engineered DNA system more versatile.