Anti-inflammatory Lanostanoids and Lactone Derivatives from Antrodia camphorata

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• 作者：Chih-Chuang Liaw ; Yu-Chang Chen ; Guan-Jhong Huang ; Yao-Ching Tsai ; Shih-Chang Chien ; Jyh-Horng Wu ; Sheng-Yang Wang ; Louis Kuoping Chao ; Ping-Jyun Sung ; Hui-Chi Huang ; Yueh-Hsiung Kuo
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：489-494
• 全文大小：285K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

Four new lanostanoids, ethyl lucidenate A (1), ethyl lucidenate F (2), 15-O-acetylganolucidate A (3), and 3,11,15,23-tetraoxo-27尉-lanosta-8,16-dien-26-oic acid (4), and two new lactone derivatives, 5-hydroxy-5-(methoxymethyl)-4-methylfuran-2(5H)-one (5) and 3-(4-methoxy-2-oxo-2H-pyran-6-yl)propanoic acid (6), together with four known compounds, 11伪-hydroxy-3,7-dioxolanost-8,24(E)-dien-26- oic acid (7), 3,7,11-trioxo-5伪-lanosta-8,24(E)-dien-26-oic acid (8), methyl 3,7,11,12,15,23-hexaoxo-5伪-lanost-8-en-26-oate (9), and ethyl 3,7,11,12,15,23-hexaoxo-5伪-lanost-8-en-26-oate (10), were characterized from Antrodia camphorata. The structures of these new compounds were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Ten components were evaluated for anti-inflammatory activity by examining their effect on LPS-iNOS-dependent NO production in murine macrophage (RAW 264.7) cells. Among them, compounds 1, 3, 7, 8, 9, and 10 significantly suppressed the NO concentration in LPS-treated RAW 264.7 cells with IC₅₀ values 鈮?10 渭M.