Anti-Hepatitis C Virus Dinorditerpenes from the Roots of Flueggea virosa

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• 作者：Chih-Hua Chao ; Ju-Chien Cheng ; De-Yang Shen ; Tian-Shung Wu
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：January 24, 2014
• 年：2014
• 卷：77
• 期：1
• 页码：22-28
• 全文大小：324K
• ISSN：1520-6025

文摘

Along with four known terpenoids (1鈥?b>4), eight new dinorditerpenes (5鈥?b>12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4鈥?b>6 were determined by the Mosher鈥檚 method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC₅₀ values of 5.6, 5.0, 7.5, and 6.6 渭M, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.