Expeditious Synthesis of 2-Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy
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- 作者：Feng-Cheng Jia ; Zhi-Wen Zhou ; Cheng Xu ; Qun Cai ; Deng-Kui Li ; An-Xin Wu
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：September 4, 2015
- 年：2015
- 卷：17
- 期：17
- 页码：4236-4239
- 全文大小：395K
- ISSN：1523-7052
文摘
A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved consecutive iron-mediated [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cyclization, oxidation, and copper-catalyzed denitrogenation sequences. The formed structure is the privileged core in drugs and bioactive molecules.