Iron Porphyrin-Catalyzed Three-Component Reaction of Ethyl Diazoacetate with Aliphatic Amines and 尾,纬-Unsaturated 伪-Keto Esters
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- 作者：Chaoqun Ma ; Dong Xing ; Changwei Zhai ; Jiuwei Che ; Shunying Liu ; Jue Wang ; Wenhao Hu
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：December 20, 2013
- 年：2013
- 卷：15
- 期：24
- 页码：6140-6143
- 全文大小：247K
- 年卷期：v.15,no.24(December 20, 2013)
- ISSN：1523-7052
文摘
An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and 尾,纬-unsaturated 伪-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of 尾-hydroxy-伪-amino esters are produced in high yields with excellent regioselectivities.