Base-Promoted 尾-C(sp3)鈥揌 Functionalization of Enaminones: An Approach to Polysubstituted Pyridines
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- 作者：Jinhai Shen ; Dingding Cai ; Changsheng Kuai ; Yunqi Liu ; Ming鈥檈 Wei ; Guolin Cheng ; Xiuling Cui
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：July 2, 2015
- 年：2015
- 卷：80
- 期：13
- 页码：6584-6589
- 全文大小：454K
- ISSN：1520-6904
文摘
A convenient 鈥渙ne-pot鈥?base-promoted synthesis of polysubstituted pyridines from 1-arylethylamines and ynones through the direct 尾-C(sp3)鈥揌 functionalization of enaminones under metal-free conditions has been developed. An intermolecular Michael addition reaction and an intramolecular condensation were involved in this procedure, which features high regioselectivity, high efficiency, and environmental friendliness. Various polysubstituted pyridines were provided in up to 92% yield for 34 examples.