Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

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• 作者：Micael R. Cunha ; Maurício T. Tavares ; Camila F. Carvalho ; Nuno A. T. Silva ; Alfredo D. F. Souza ; Gustavo J. V. Pereira ; Fábio F. Ferreira ; Roberto Parise-Filho
• 刊名：ACS Sustainable Chemistry & Engineering
• 出版年：2016
• 出版时间：April 4, 2016
• 年：2016
• 卷：4
• 期：4
• 页码：1899-1905
• 全文大小：404K
• ISSN：2168-0485

文摘

Sulfonyl hydrazones were synthesized by one-pot reaction using sulfonyl chlorides, hydrazine hydrate and aldehydes under mild, cheap and environmental safe conditions. The optimized reaction afforded nine products with yields higher than 94% and four products with yields between 34% and 83%. Also, this paper reports, for the first time, the reduction of hydrazine amount (1.2 equiv) in sulfonyl hydrazones synthesis, presenting an excellent perspective to the sustainable production of new drug candidates.