Calophyline A, a New Rearranged Monoterpenoid Indole Alkaloid from Winchia calophylla
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- 作者：Li-Mei Li ; Tai Yang ; Yang Liu ; Jin Liu ; Min-Hui Li ; Yan-Tang Wang ; Shu-Xia Yang ; Qiang Zou ; Guo-You Li
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：July 6, 2012
- 年：2012
- 卷：14
- 期：13
- 页码：3450-3453
- 全文大小：240K
- 年卷期：v.14,no.13(July 6, 2012)
- ISSN：1523-7052
文摘
Calophyline A (1), a novel unprecedented rearranged monoterpenoid indole alkaloid, along with a new natural product N-methyl aspidodasycarpine (2) and six known analogues, was isolated from the trunk barks of Winchia calophylla. The structure of compound 1 was elucidated on the basis of spectroscopic data and then confirmed by a single-crystal X-ray crystallographic analysis. A hypothetical biogenetic pathway for compound 1 was proposed. All isolated compounds were evaluated for their in vitro cytotoxicity against a small panel of human cancer cell lines.