Terpenoid Indole Alkaloids from Winchia calophylla

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• 作者：Li-She Gan ; Sheng-Ping Yang ; Yan Wu ; Jian Ding ; and Jian-Min Yue
• 刊名：Journal of Natural Products
• 出版年：2006
• 出版时间：January 2006
• 年：2006
• 卷：69
• 期：1
• 页码：18 - 22
• 全文大小：158K
• 年卷期：v.69,no.1(January 2006)
• ISSN：1520-6025

文摘

Three new indole alkaloids, N(4)-demethyl-12-methoxyalstogustine (1), 17-carboxyl-N(4)-methylechitamidine chloride(2), and 17-carboxyl-12-methoxy-N(4)-methylechitamidine chloride (3), along with 15 known alkaloids, were isolatedfrom the ethanolic extract of the stem bark of Winchia calophylla. The structures of 1-3 were elucidated on the basisof spectroscopic means and chemical methods. The determination of relative configurations at C-19 and C-20 for 1-3was aided by ¹³C NMR spectroscopic data. The absolute configurations of alkaloids 1-3 were determined by directcomparison of their CD spectra with those of known alkaloids. All the alkaloids were tested in cytotoxic assays againstP-388 and A-549 tumor cell lines, and only two of them showed weak activity against the A-549 cell line.