One-Pot Synthesis of Benzo[4,5]imidazo[2,1-a]isoquinolines and Isoquinolino[3,4-b]quinoxalines via Tandem Cyclization Strategies
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- 作者：Alex L. Bagdasarian ; Huy H. Nguyen ; Teresa A. Palazzo ; James C. Fettinger ; Makhluf J. Haddadin ; Mark J. Kurth
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：May 6, 2016
- 年：2016
- 卷：81
- 期：9
- 页码：3924-3928
- 全文大小：332K
- 年卷期：0
- ISSN：1520-6904
文摘
Two operationally simple one-pot protocols have been developed for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-a]isoquinolines and isoquinolino[3,4-b]quinoxalines. Optimization data and substrate scope for these atom-economical transformations, which engage commercially available o-phenylenediamines and o-cyanobenzaldehydes, are discussed.