A Novel Approach to Indoloditerpenes by Nazarov Photocyclization: Synthesis and Biological Investigations of Terpendole E Analogues

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• 作者：Ftima Churruca ; Manolis Fousteris ; Yuichi Ishikawa ; Margarete von Wantoch Rekowski ; Candide Hounsou ; Thomas Surrey ; Athanassios Giannis
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 7, 2010
• 年：2010
• 卷：12
• 期：9
• 页码：2096-2099
• 全文大小：185K
• 年卷期：v.12,no.9(May 7, 2010)
• ISSN：1523-7052

文摘

The application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described.