Gemini Imidazolium Amphiphiles for the Synthesis, Stabilization, and Drug Delivery from Gold Nanoparticles
详细信息 查看全文
- 作者：Luc铆a Casal-Dujat ; Mafalda Rodrigues ; Alex Yag眉e ; Anna C. Calpena ; David B. Amabilino ; Javier Gonz谩lez-Linares ; Miquel Borr脿s ; Llu茂sa P茅rez-Garc铆a
- 刊名：Langmuir
- 出版年：2012
- 出版时间：February 7, 2012
- 年：2012
- 卷：28
- 期：5
- 页码：2368-2381
- 全文大小：675K
- 年卷期：v.28,no.5(February 7, 2012)
- ISSN：1520-5827
文摘
Gold nanoparticles (AuNPs) are considered useful vehicles for medical therapy and diagnosis. Despite the progress made in this field, there is need to find direct, reliable, and versatile synthetic procedures for their preparation as well as new multifunctional coating agents. In this sense, we have explored the use of imidazolium amphiphiles to prepare new AuNPs designed for anion recognition and transport. Thus, in this work we describe (a) the synthesis, by a phase transfer method, of new gold nanoparticles using gemini-type surfactants as ligands based on imidazolium salts, those ligands acting as transfer agents into organic media and also as nanoparticle stabilizers, (b) the examination of their stability in solution, (c) the chemical and physical characterization of the nanoparticles, using a variety of techniques, including UV鈥搗isible spectroscopy (UV鈥搗is), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS), (d) toxicity data concerning both the imidazolium ligands and the imidazolium coated nanoparticles, (e) the assessment of their molecular recognition ability toward molecules of biological interest, such as anions and carboxylate containing model drugs, such as ibuprofen, (f) the study of their toxicity and those of their coating ligands, as well as their ability for cell internalization, and (g) the study of their ability for delivering anionic pharmaceuticals. The structurally governed triple role of those new gemini-type surfactants is responsible for the preparation, remarkable stability, and delivery properties of these functional AuNPs.