Silver(I) 1,3,5-Triaza-7-phosphaadamantane Coordination Polymers Driven by Substituted Glutarate and Malonate Building Blocks: Self-Assembly Synthesis, Structural Features, and Antimicrobial Properties

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• 作者：Sabina W. Jaros ; M. Fátima C. Guedes da Silva ; Magdalena Florek ; Piotr Smoleński ; Armando J. L. Pombeiro ; Alexander M. Kirillov
• 刊名：Inorganic Chemistry
• 出版年：2016
• 出版时间：June 20, 2016
• 年：2016
• 卷：55
• 期：12
• 页码：5886-5894
• 全文大小：546K
• 年卷期：0
• ISSN：1520-510X

文摘

Three new bioactive silver(I) coordination polymers formulated as [Ag₂(μ₂-PTA)(μ₃-PTA)(μ₂-pga)(H₂O)]_n·6H₂O (1), [Ag₂(μ₂-PTA)(μ₃-PTA)(Hpmal)₂]_n·2H₂O (2), and [Ag(μ₃-PTA) (Hdmga)]_n (3) were self-assembled from Ag₂O, 1,3,5-triaza-7-phosphaadamantane (PTA), and a substituted dicarboxylic acid (3-phenylglutaric acid (H₂pga), phenylmalonic acid (H₂pmal), or 3,3-dimethylglutaric acid (H₂dmga)) as an ancillary ligand. Compounds 1–3 were fully characterized by IR and NMR spectroscopy, ESI-MS(±), elemental analysis, and single-crystal X-ray diffraction, revealing that their architectural and topological diversity is governed by structural modulation of a dicarboxylate building block. The structures vary from a 1D cyclic chain with the SP 1-periodic net (4,4)(0,2) topology in 2 to distinct 2D metal–organic layers with the cem-d and hcb topologies in 1 and 3, respectively. In addition, compounds 1–3 exhibit a notable antimicrobial efficiency against a panel of common Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) bacteria and yeast (C. albicans). The best normalized minimum inhibitory concentrations (normalized MIC) of 11–23 nmol mL^–1 (for bacterial strains) or 68 nmol mL^–1 (for a yeast strain) are shown by compound 2, and the eventual structure–bioactivity correlations are discussed.