Design, Synthesis, and Photochemistry of Modular Caging Groups for Photoreleasable Nucleotides

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• 作者：Toshiaki Furuta ; Kaori Manabe ; Aoi Teraoka ; Kanako Murakoshi ; Ai Ohtsubo ; Akinobu Suzuki
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：14
• 期：24
• 页码：6182-6185
• 全文大小：226K
• 年卷期：v.14,no.24(December 21, 2012)
• ISSN：1523-7052

文摘

A modular approach to preparing caged nucleotides having additional properties has been achieved. The modular caging agent includes three components: an amine reactive NHS ester moiety, a photoactive Bhc group, and tosylhydrazone as a precursor of the diazomethyl group. Various amines including biotin and an Arg-Gly-Asp (RGD) peptide were introduced into the key intermediate via amide linkage. The Bio-Bhc-diazo thus synthesized enables the preparation of a photoreleasable siRNA with additional properties.