Investigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytonemin

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• 作者：Emily P. Balskus ; Christopher T. Walsh
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：November 19, 2008
• 年：2008
• 卷：130
• 期：46
• 页码：15260-15261
• 全文大小：120K
• 年卷期：v.130,no.46(November 19, 2008)
• ISSN：1520-5126

文摘

The cyanobacterial natural product scytonemin (1) functions as a sunscreen, absorbing harmful UV-A radiation. Using information from a recently identified gene cluster, we propose a biosynthetic route to this pigment. We also report the characterization of two enzymes, NpR1275 and NpR1276, which are involved in the initial stages of this pathway. A regioselective acyloin reaction between indole-3-pyruvic acid (4) and p-hydroxyphenylpyruvic acid (5) is a key step in assembling the carbon framework of a proposed monomeric scytonemin precursor (2).