Supramolecular Self-Assembly of Cyclodextrin and Higher Water Soluble Guest: Thermodynamics and Topological Studies

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• 作者：Frederico B. De Sousa ; A&#x302 ; ngelo M. Leite Denadai ; Ivana S. Lula ; Clebio S. Nascimento Jr. ; Natha&#x301 ; lia S. G. Fernandes Neto ; Ana C. Lima ; Wagner B. De Almeida ; Rube&#x301 ; n D. Sinisterra
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：July 2, 2008
• 年：2008
• 卷：130
• 期：26
• 页码：8426 - 8436
• 全文大小：1804K
• 年卷期：v.130,no.26(July 2, 2008)
• ISSN：1520-5126

文摘

The supramolecular interactions between Imipramine hydrochloride (IMI), a tricyclic antidepressant, and β-cyclodextrin (βCD) have been investigated by experimental techniques and theoretical calculations. The association between these molecules might be lead to a host/guest compound, in which the physical chemistry properties of the guest molecule, such as high solubility, can be decreased. These new properties acquired by the inclusion phenomena are important to develop a strategy for pharmaceutical formulation. Nuclear magnetic resonance and horizontal attenuated total reflectance provided relevant information on the complex stoichiometries and the sites of interactions between the host and guest molecules. Stoichiometries of 1:2, 1:1, and 2:1 βCD/IMI have been detected in solution. Self-diffusion coefficient and dynamic light scattering analysis provided information on the self-aggregation of the complex. Also, isothermal titration calorimetry studies indicated the existence of equilibrium between different complexes in solution. In order to determine the preferred arrangement for the inclusion complex formed by the IMI molecule and βCD, theoretical calculations were performed. Of all proposed supramolecular structures, the 2:1 βCD/IMI complex was calculated to be the most energetically favorable, in both gas and aqueous phases. The calculations indicated that the intermolecular hydrogen bonds involving the hydroxyl groups of βCD play a major role in stabilizing the supramolecular 2:1 structure, corroborating experimental findings.